Cairo University

MTPR Journal

 

Thin Film Applications in Wound Healing

2019-04-21
Heba M. Fahmy1,AlaaWesal Abd Ellatef2,Alaa M. Elsayed3,Asmaa Mamdouh Ahmed1,M.Hamdy El-Hakim1,Fayrouz Ali el Baioumy5, MarwaA. Abd Elazim6
1: Bioph. Dept., Faculty of Science, Cairo Univ., EGYPT.
2: Bioph. Dept.,woman Faculty of Science, Ain Shams Univ., EGYPT
3 : Zoology &chemistry Depart., Faculty of Science, Cairo Univ., EGYPT
4:Chemistry&Biochemistry Depart., Facultyof Science,CairoUniv., EGYPT
5: Biochemistry Dept.,Faculty of Science, Ain Shams Univ., EGYPT
6: Chemistry Depart.,Faculty of Science, Helwan Univ., EGYPT

Vol./Issue: 19 , id: 294

Wound healing becomes more efficient and easier by the aid of thin films. Gelatin production of thin films used for wound dressing is due to its high curative effect, antibacterial and the easy way to form it as a thin film. Many studies were made on bacterial cultures to uncover the role of the gelatin thin films in the wound healing treatment process.Silk/gelatin (S/G) film displays excellent mechanical properties which is essential for wound healing applications which cannot be obtained from sole gelatin film. Collagen films have a good effect in improving wound healing process. One of the gel for wound healing purposes is Aloe vera gel which enhances the degree of collagen cross-linking and the synthesis of collagen after topical and systemic administration in wounds created in a diabetic rat model. Aloe vera-Ca-alginate films shows intrinsic properties of wound healing process like the flexibility and high transparency.Chitosan has been used for years in wound healing because of its ability to stimulate healing process, being nontoxic and has biodegradable properties. After the preparation of the previously mentioned thin films, some tests are carried on to show how these thin films affect wound healing process like characterization of films by FTIR, SEM. Also, for each thin film type, physical properties: like: water vapour permeability, oxygen transmission rate, antimicrobial activity and antioxidant activity are studied.In vivo and Vitro experiments demonstrated that these films showed antibacterial activity, decrease in wound size, low swelling behavior, nontoxicity and tissue repairing etc.