Cairo University

MTPR Journal

 

Thin Film Applications in Wound Healing

2019-04-21
Heba Mohamed Fahmy1; Nashwa MoatezEbrahim٢; AlaaWesal Abd Ellatef٣; Mariam Hisham Mohamed ٤; Fayrouz Ali el Baioumy٥; Asmaa Mamdouh Ahmed٦; Marwa Ahmed Abd Elazim٧; Alaa Mohammed Alaam٨; Mohamed Hamdy Mahmoud9
1: Biophysics Department, Faculty of Science, Cairo University, Egypt.
2:Biophysics Department, Faculty of science, Ain shams university, Egypt
3: Biophysics Department,woman faculty of science, Ain Shams University,Egypt
4: Biophysics Department, Faculty of Science, Cairo University, Egypt.
5: Biochemistry Department,faculty of science, Ain Shams University, Egypt
6:chemistry&Biochemistry Department,Facultyof Science,CairoUniversity, Egypt.
7: Chemistry Department, faculty of science, Helwan University, Egypt.
8: Zoology &chemistry Department, Faculty of Science, Cairo University, Egypt.
9: Biophysics Department,Faculty of Science, Cairo University, Egypt.

Vol./Issue: 19 , id: 287

Wound healing becomes more efficient and easier by the aid of thin films. Gelatin production of thin films used for wound dressing is due to its high curative effect, antibacterial and the easy way to form it as a thin film. Many studies were made on bacterial cultures to uncover the role of the gelatin thin films in the wound healing treatment process. Silk/gelatin (S/G) film displays excellent mechanical properties which is essential for wound healing applications which cannot be obtained from sole gelatin film.Collagen is mostly found in fibrous tissues. It is important in tissue engineering and cosmetic medicine. Collagen films which are prepared from Brazilian propolis or chitosan have a good effect in improving wound healing process when it works as wound dressing for dermal burn healing. One of the gel for wound healing purposes is Aloe vera gel which enhances the degree of collagen cross-linking and the synthesis of collagen after topical and systemic administration in wounds created in a diabetic rat model. Aloe vera-Ca-alginate films shows intrinsic properties of wound healing process like the flexibility and high transparency.Chitosan is a cationic natural polymer and a natural polysaccharide that has been used for years in wound healing because of its ability to stimulate healing process, being nontoxic and has biodegradable properties.The properties of chitosan can be developed by incorporating it with substances which have properties that can increase the efficiency of chitosan. These substances are like thyme oil, ECM from porcine omentum and also by using castor oil as matrix material in the production of biocompatible and biodegradable non composite film containing chitosan modified ZnO nanoparticle, curcumin, as gelatin, tourmaline, polyvinyl alcohol/sodium carboxy methyl cellulose, polyvinylpyrrolidone, Poly (vinyl alcohol), Methoxy-poly (ethylene glycol) etcand with others to improve efficiency of chitosan film in wound healing process.After the preparation of the previously mentioned thin films, some tests are carried on to show how these thin films affect wound healing process like characterization of films by FTIR, SEM. Also, for each thin film type, physical properties: like: water vapor permeability, oxygen transmission rate, antimicrobial activity and antioxidant activity are studied.In vivo and Vitro experiments demonstrated that these films showed antibacterial activity, decrease in wound size, low swelling behavior, nontoxicity and tissue repairing etc.