Cairo University

MTPR Journal


Grape seed derivatives in cancer treatment

Heba Mohamed Fahmy Abdelbaky1, Mostafa Mohamed Ahmed Sayed2, Fatma Mohamed Fouad3, Alaa Ali4, Soha salah abdelhamied5, latifa Helmy Ahmed6, Ayat Mosstafa Saadeldin7
1 Biophysics Department, Cairo University, Egypt.
2 Chemistry / Microbiology Department, Faculty of Science, Cairo
University, Egypt.
3 Biotechnology Department, Faculty of Science, Cairo University, Egypt.
4Faculty of Physiotherapy, Cairo University, Egypt.
5 Chemistry/Biochemistry Department, Cairo University, Egypt.
6 Biophysics/Chemistry Department, Alexandria University, Egypt.
7 Radiation Oncology Department, Elhussein University Hospital, Cairo,

Vol./Issue: 19 , id: 284

In the last decades, there is an increasing concern to new and safe medications to treat cancer which is becoming a widespread problem all over the world. Grape seed extracts proved to have a role in the management of cancer, they enhance the effect of chemo adjuvant treatment or prevent progression. Previous work demonstrated that Grape seed derivatives likeprocyandine B23,3"-di-o-gallate showed a great effect in the treatment of prostate cancer. Resveratrol, which is considered, asis a type of polyphenols had proved therapeutic potential against colon cancer, in addition, Alphalinolenic acid showed promising effects in the treatment of skin, breast and esophageal cancers. Moreover, polyphenols demonstrated a success in the treatment of different types of cancer and their effects was dose and time dependent. The present work reviewsa number of previous studies that used grape seed or one of its derivatives in the management of cancer.