In the last decades, there is an increasing concern to new and safe medications to treat cancer which is becoming a widespread problem all over the world. Grape seed extracts proved to have a role in the management of cancer, they enhance the effect of chemo adjuvant treatment or prevent progression. Previous work demonstrated that Grape seed derivatives likeprocyandine B23,3"-di-o-gallate showed a great effect in the treatment of prostate cancer. Resveratrol, which is considered, asis a type of polyphenols had proved therapeutic potential against colon cancer, in addition, Alphalinolenic acid showed promising effects in the treatment of skin, breast and esophageal cancers. Moreover, polyphenols demonstrated a success in the treatment of different types of cancer and their effects was dose and time dependent. The present work reviewsa number of previous studies that used grape seed or one of its derivatives in the management of cancer.
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