Cairo University

MTPR Journal

 

ELECTROPORATION AS A NOVEL METHOD FOR FLUOXETINE LOADING

2019-04-21
Heba Mohamed Fahmy 1, Aya Allah ashrafshafie2, Abeer Ashraf Abdelmokhtar1 , Mohamed Hamdy Mahmoud1, Yousra Mohamed Yousef2, Abdelaziz Habib Mohamed1, Asmaa Mamdouh Ahmed2, Naglaa Abd El-Monaem Taha3, Fatma El-Zahra Mahmoud Hassan2, Fayrouz Ali Muhammad4 , Esraa Mohammed Abd Al-Mohsen 5.
1: Biophysics Department, Faculty of Science, Cairo University, Egypt.
2: Biochemistry Department, Faculty of Science, Cairo University, Egypt.
3: Zoology/Chemistry Department, Faculty of science, Mansoura University, Egypt.
4: Biochemistry Department, Faculty of Science, Ain Shams University, Egypt.
5: Medical Physics Department, Faculty of applied Science, Umm Al-Qura University,
KSA

Vol./Issue: 19 , id: 281

For the treatment of diseases, not only the drug industry is important, but how to target the drug to the affected area with minimal damage and the highest concentration is what scientists are interested in. This project aims to apply a more effective and less expensive method of delivery of fluoxetine (FLX) which is used as a treatment for depression but has terrible side effects on the human body. The method depends on applying the technique of electroporation on FLXloaded liposome. The project is divided into two phases, the first is to enter FLX into non-doped DPPC-liposome using electroporation, and the second phase is the use of electroporation for the entrance of FLX into DPPC liposome doped with silver nanoparticles. The present study extends also to compare the results of the two phases and find out which method and what kind of liposome is better to transport the drug with higher encapsulation efficiency.