Cairo University

MTPR Journal

 

Fast Diagnoses of Cancer by Isotopic Variations Detection in Blood Samples Using Laser spectroscopic Technique

2019-04-22
H. Imam 1, Ola. S. Ahmed2, Abdel-Rahman Zekri2, M. Hafaz1, Elsh. Omra1, G.Omar3
1National Institute of Enhanced laser NILES, Cairo Univreisty, Egypt.
2National Cancer institute, Cairo University, Egypt.
3National institute of Oceanography and fisheries, Egypt

Vol./Issue: 19 , id: 270

The early detection of cancer is of prime importance with respect to treatment and patient survival. Biopsy techniques that are currently employed for such diagnosis are invasive and time consuming.Isotopic analysis is essential in medicine, chemistry, materials science, radiochemistry, archeology, and nuclear non-proliferation.Isotopic data provide answers to fundamental questions related to research and development in these disciplines as well as providing important insight into more applied fields.A new method of performing optical isotopic analysis of condensed samples in ambient air and at ambient pressure will be developed: Laser Induced Breakdown Spectrometry (LIBS). This technique is currently a subject of great interest in spectroscopy and is being considered for the design of a field portable unit for nuclear safeguard inspection, because it allows a high level of portability and versatility while identifying the elements and materials of interest. The new method can determine not only chemical composition but also isotopic ratios of elements in the sample. Isotopic measurements are enabled by significantly larger isotopic shifts found in molecular spectra relative to atomic spectra. No sample preparation or pre-treatment is required. Detection of the isotopes of copper, zinc and sulfur will be discussed to illustrate the isotopes ratio of these elements as marker for cancer type. It is possible to build a model that enables the accurate determination of the isotopic ratio under conditions for elements of interest would not be achievable without the use of ultra-high resolution spectrometer. The performance obtained with such a LIBS sensor configuration demonstrates the possibility of integrating all of the required components in a small portable handheld system. That will lead to make the whole investigation of cancer type and grades using a new developed technique.