In this work we synthesis bimetallic silver–gold nanoparticles (NPs) with different structures. Namely, (AuCore-AgShell) and (AgCore-AuShell) nanoparticles were synthesized in double distilled water by Pulsed Laser Ablation in Liquid (PLAL)without any stabilizers or surfactant. Although, laser ablation during surfactant is possible.The morphological and structural properties of the resulting bimetallic nanoparticles were thoroughly analyzed by TEM, DLS, and UV–Vis spectrophotometry. The plasmon band of the two core–shell NPs ranged from approximately 400 to 520nm. For AuCore-AgShell the plasmon band of core–shell NPs can be shifted to lower wavelengths (blue shift) by depositing a silver shell with increasing ablation time of the silver target. On the other side for AgCore-AuShell shifted to higher wavelengths (red shift) by depositing a gold shell with increasing ablation time of the gold target. Furthermore, UV–Visible optical absorption spectroscopy indicated the deviation of the surface plasmon resonance peaks with the Au and Ag shell by variation of the laser pulse ablation time, which affected the shell thickness.The HRTEM images clearly confirm the spherical colloidal stable with two different structures of the two core shell nanoparticles CS- NPs. The effect of cellular uptake of Au, Ag, (AuCore-AgShell) and (AgCore-AuShell) nanoparticles on cell adhesion/viability, cytotoxicity and morphology of Liver cancer cells culture (HePG2) have been investigated.
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