Cairo University

MTPR Journal


Evaluation of the efficiency of 99mTc-DMSA as a radiopharmaceutical in dynamic renal scans

Heba M Fahmy1*, Hossam M Yassin2, Islam M Muhamed1, Samar E Mohamed1, Shimaa S Hassan1
1: Biophysics Department, Faculty of Science, Cairo
2: Cairo University Hospital

Vol./Issue: 16 , id: 250

In dynamic renal scans, 99mTc-diethylenetriamine pentaacetic acid (DTPA) is much used and give information about the renal blood-flow and excretory function. 99mTc-dimercaptosuccinic acid (DMSA) is employed for static renal imaging and can show also the renal cortical structure. The purpose of this work was to evaluate whether DMSA can be utilized as a radiopharmaceutical in dynamic renal scans or not. The aim extends also to compare the results obtained from DMSA with those obtained with DTPA scans. A comparison of the data obtained from the renograms of 47 subjects (normal subjects and abnormal renal function patients having: obstructive nephropathy, bilateral nephropathy, hydro-nephrosis, reduced or non-function kidney and/or atrophic kidney) that had 99mTc-DMSA and 99mTc-DTPA dynamic scintigraphies using the same protocol. Estimation of the left kidney, right kidney and the total glomerular filtration rate (GFR) from 99mTc-DTPA and 99mTc-DMSA renograms showed a strong positive correlation.Moreover, estimation of the time of the peak height from 99mTc-DTPA and99m Tc- DMSA renograms for the right and left kidneys showed non-significant changes and strongpositive correlation for both the normal subjects and patients with kidney abnormalities. In the light of the results obtained from the present study, it could be suggested that 99mTc-DMSA could be successfully replace99mTc- DTPA in dynamic renograms in the case of the renal conditions that had been studied in the present work. This will be money and time consuming, and will lower the radiation dose to the patients. In addition, the same qualities of results are obtained with both radiopharmaceuticals in normal subjects and abnormal renal function patients.