Nano-hydroxyapatite/chitosan (n-HAP/CS) biocomposites with high compressive strength were synthesized by microwave coprecipitation assisted. HAP was doped with both Mg2+ and Ag+ simultaneously as the formula: [MgxAgyCa(10-x-y)(PO4)(OH)2] ;[0≤(x+y)≤1]. The samples were characterized by Fourier transform infra-red spectroscopy (FTIR), X-ray diffraction (XRD) and high resolution transmission electron microscopy (HRTEM). The results showed that the shape, size and crystallinity index of nano-HAP crystals in composites were similar to that of natural bone. Ag+ presents high impact in improving anti-bacterial effect, in addition; Mg2+dopant was a crucial factor in progressing the mechanical properties. Furthermore, mechanical testing exhibited that the maximum compressive strength of the composite materials was 15 MPa. The measured density was in range of 1.12-1.43 g/cm3. Multifunctional non-sintered materials show promising results in drug loaded bioceramics with improved mechanical features in bone tissue engineering.
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