Cairo University

MTPR Journal

 

TOWARDS DIAGNOSTICS and MONITORING of DISEASE BIOMARKERS in EXHALED BREATH USING FREQUENCY COMB LASER

2016-12-17
T. Mohamed1,2, F. Zhu1 , J. Strohaber1 , A. A. Kolomenskii1 , and Hans A Schuessler1
1Department of Physics and Astronomy, Texas A&M
University, College Station, TX 77843, USA
2Laser Institute for Research and Applications LIRA, Beni-
Suef University, Beni Suef 62511, Egypt

Vol./Issue: 16 , id: 191

Breath analysis is a non-invasive method for monitoring the volatile organic compounds present in the human breath and is one of the clinical tests that can be used for early disease detection. The advantages of breath analysis in comparison to blood or urine analysis includes it is non-invasive, easily repeated, and does not cause any infections. In this connection an optical setup based on a frequency comb laser and a multipass optical cell has been developed for breath analysis. The multipass optical cell is formed by six highly reflective confocal mirrors to achieve long optical path of 600 m in a cell of only of 0.5 m in length. The frequency comb lasers are a broadband fiber laser beams with spectral range spanning from 1500 nm to 1700 nm and from 3100 to 3400 nm. The relevant spectrum covers many biomarkers, including ethane, acetone, methane, ethylene, carbon dioxide, carbon monoxide, ammonia, and methylamine. For testing the optical setup, the absorption laser spectroscopy measurements in the near/mid IR of acetone, methane, carbon dioxide, carbon monoxide gasses were carried out. For methane and acetone a signal to noise ratio of 120 was obtained and the detection limits were ~ 1.5 ppmv and ~ 2 ppmv respectively. Also a brief description of a new laser facility at Beni-Suef University, Egypt will be discussed during the conference.