We applied the 4D AFM to:
First: Film the landing of individual, flexible nanomolecules onto atomically flat surfaces from a very diluted aqueous drop. How these nanomolecules start making a monolayer? How they behave when they just meet a single, free moving biomolecules (DNA in this study)? Finally, how we applied these results in producing individual, targeted nanoparticles for cancer treatment?
Second: Image in nanoscopic scale the DNA damage bysmall and large Au NPsin near physiological conditions.
Finally: Capturethe mechanism(s) of enzymaticaction on a very short RNA rods. We believe that these points will increase the application of 4D-AFM in biophysics and Nanomedicine.
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