Cairo University

MTPR Journal

 

THE APPLICATION OF ATOMIC FORCE MICROSCOPY (AFM) IN NANO-BIOPHYSICS

2016-12-17
Hosam Gharib Abdelhady
College of Pharmacy-Taibah University-Almadinah
Almunawarrah-KSA
Bioavailability Center-NODCAR-Cairo-Egypt

Vol./Issue: 16 , id: 187

We applied the 4D AFM to:

First: Film the landing of individual, flexible nanomolecules onto atomically flat surfaces from a very diluted aqueous drop. How these nanomolecules start making a monolayer? How they behave when they just meet a single, free moving biomolecules (DNA in this study)? Finally, how we applied these results in producing individual, targeted nanoparticles for cancer treatment?

Second: Image in nanoscopic scale the DNA damage bysmall and large Au NPsin near physiological conditions.

Finally: Capturethe mechanism(s) of enzymaticaction on a very short RNA rods. We believe that these points will increase the application of 4D-AFM in biophysics and Nanomedicine.