In this study, TiO2 nano-crystalline structures are fabricated using the LP-PLA technique. Nano-structural investigation was carried out by Electron Microscopy Measurements TEM, HRTEM, SEM , EDX and Electron Diffraction measurements. Optical properties were also determined by measuring absorption, emission and luminescence spectra of the Nano-crystalline TiO2. We then prepared a simple self-cleaning paint loaded with the TiO2 nanocrystals of different structural and/or optical properties. Coatings of the paint were made on aluminum, stainless steel and plastic surfaces representing materials applied in preserving food and medical systems. Self-cleaning of outdoor surfaces such as ceramics and cementious materials used in buildings were prepared by immediate loading with TiO2 nanoparticles and tested. In order to verify self-cleaning performances of photocatalytic cements/concretes, tests mainly based upon the degradation of methylen blue color and measuring the water contact angle for providing self-cleaning performances were carried out for materials. The experimental results introduce new information on visible light photocatalytic technologies of nano- TiO2 in providing self cleaning and antimicrobial surfaces often used in the open environment such as every day use of home utensils, buildings, and medical needed hygienic tools.